Genetics Fundamentals
The foundational concepts that the rest of the site builds on: how DNA encodes information, how variants arise and are inherited, how genetic risk is estimated, and how genetic information enters clinical and longevity decisions. Educational content, never medical advice.
core biology
Chromosomes & Genome Organization
The human genome is not a loose tangle of DNA but a precisely packaged, folded structure. Nearly...
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DNA, RNA & Proteins: The Central Dogma
Every living cell runs on a one-directional flow of information. The sequence stored in DNA is co...
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Genetic Variants: SNPs, Indels, CNVs & Structural Variation
Every person carries a genome that differs from the reference at roughly four to five million sit...
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Genotype vs. Phenotype
A person's genotype is the exact set of gene variants they carry; their phenotype is what actuall...
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Inheritance Patterns
Inheritance is the set of rules that decide which versions of a gene a child receives from each p...
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Introduction to Genetics
Genetics is the study of how living things store, copy, and pass on the instructions for building...
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Penetrance, Expressivity & Pleiotropy
Two people can inherit the same disease mutation and live different lives: one develops the illne...
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Polygenic Risk Scores
A polygenic risk score takes the thousands of tiny genetic nudges scattered across a person's gen...
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